浙江大学医学院导师介绍：陈怀增

姓名：陈怀增
性别：男
所在学院：医学院
职称：副研究员
研究方向：
妇科肿瘤
发表论文：
1．Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinomaLoss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous cEuropean Journal of Gynacological Oncology28<6>,Chen H,Ye F,Zhang J,Lu W,Cheng Q,Xie X
2．No association of the POLI Thr706Ala polymorphism with the risk of cervical carcinomaNo association of the POLI Thr706Ala polymorphism with the risk of cervical carcinomaEuropean Journal of Gynacological Oncology<>,Zhang J,Ye F,Cheng Q,Shen J,Chen H
1．Tapasin和HLAⅠ类分子在人卵巢癌中的表达及相关性Tapasin和HLAⅠ类分子在人卵巢癌中的表达及相关性14<4>,
2．人乳头瘤病毒的分子生物学特性研究现状人乳头瘤病毒的分子生物学特性研究现状28<4>,
3．卵巢癌细胞死亡形式对巨噬细胞细胞毒作用的影响中华妇产科杂志39<4>,楼海亚，叶大风，陈怀增，吕卫国，付云峰，谢幸
4．Interleukin-7 and suppression of local peritoneal immunity in ovarian carcinomaInterleukin-7 and suppression of local peritoneal immunity in ovarian carcinomaInternational Journal of Gynecology and Obstetrics85<>,X． Xie,D． Ye,H． Chen,W． Lu,B． Cheng,H． Zhong
5．卵巢上皮性癌生长抑素受体2表达的研究中华妇产科杂志37<5>,陈怀增，谢幸，叶大风，吕卫国
6．卵巢粘液性肿瘤hMLHl启动子甲基化及微卫星不稳定性中国医学科学院学报25<4>,陈怀增，叶大风，谢幸，胡旻，吕卫国
7．体外γ干扰素对脐静脉内皮细胞ECV-304的作用中华医学杂志83<11>,陈怀增，林仿芳，谢幸，叶大风，吕卫国
8．γ-干扰素对卵巢癌细胞株血管内皮生长因子表达的影响中华妇产科杂志38<3>,林仿芳，陈怀增，谢幸，叶大风
9．白细胞介素7基因转染卵巢癌细胞的体外研究中华妇产科杂志38<4>,程蓓，陈怀增，叶大风，吕卫国，谢幸
10．免疫重建荷卵巢癌SKOV3 SCID鼠腹腔移植中IL-7的免疫学作用中华微生物学和免疫学杂志23<12>,叶大风，陈怀增，谢幸，吕卫国，朱华，潘子民
11．卵巢癌患者CD4＋CD25＋调节性T细胞比例增高及可能机制中华微生物学和免疫学杂志 2004；24（7）：574-575。24<7>,李晓，陈怀增，谢幸，叶大风，吕卫国，丁志明
12．VEGF、VEGFRs expressions and activated STATs in ovarian epithelial carcinoma VEGF、VEGFRs expressions and activated STATs in ovarian epithelial carcinoma Gynecol Oncol94<>,Huaizeng Chen,Dafeng Ye,Xing Xie*,Bingya Chen,Weiguo Lu
13．Mismatch Repair Gene Promoter Methylation and expression in Hydatidiform molesMismatch Repair Gene Promoter Methylation and expression in Hydatidiform molesArch Gynecol Obstet<272>,Huaizeng Chen,Dafeng Ye,Xing Xie*,Weiguo Lu,Changkun Zhu,Xiaodong Chen
14．PTEN Promoter Methylation and Protein expression in Normal Early Placentas and Hydatidiform MolesPTEN Promoter Methylation and Protein expression in Normal Early Placentas and Hydatidiform MolesJ soc gynecol invest12<>,Huaizeng Chen ,Dafeng Ye ,Xing Xie *,Weiguo Lu,Changkun Zhu and Xiaodong Chen
15．用ELISA测定卵巢癌患者血清、腹腔液VEGF水平及其临床意义浙江医学23<11>,傅云峰，谢幸，叶大风，陈怀增，吕卫国
16．卵巢上皮性癌患者白细胞介素-7测定的临床意义实用肿瘤杂志16<5>,钟惠珍，谢幸，谢建华，叶大风，吕卫国，陈怀增
17．The Value of Curettage in Diagnosis of Endometrial HyperplasiaThe Value of Curettage in Diagnosis of Endometrial HyperplasiaGynecologic Oncology84<>,Xing Xie,Wei-Guo Lu,Da-Feng Ye,Huai-Zeng Chen,Yun-Feng Fu
18．Ovarian carcinoma cells inhibit T cell proliferation:suppression of IL-2 receptor and g expression and their JAK-STAT signaling pathwayOvarian carcinoma cells inhibit T cell proliferation:suppression of IL-2 receptor and g expression aLife Sciences74<>,Hui Wang,Xing Xie*,Wei-guo Lu,Da-feng Ye,Huai-zeng Chen,Xiao Li,Qi Cheng
19．子宫内膜增殖症诊断性刮宫价值的评价中华医学杂志81<13>,吕卫国，谢幸，叶大风，陈怀增，傅云峰，陈晓端
20．卵巢上皮性癌患者28例血清和腹腔液VEGF测定及其诊断价值初探中国实用妇科与产科杂志18<10>,傅云峰，谢幸，叶大风，陈怀增，吕卫国
21．转化生长因子β1、白细胞介素2、7与卵巢上皮性癌患者腹腔局部免疫功能的关系现代妇产科进展11<5>,吕卫国，叶大风，谢幸，陈怀增，傅云峰
22．卵巢上皮癌IL-7mRNA表达的研究现代妇产科进展11<2>,程蓓，谢幸，叶大风，陈怀增，吕卫国
23．人参皂甙Rg3对荷卵巢癌的严重联合免疫缺陷鼠的抗肿瘤血管生成作用的研究中华妇产科杂志37<4>,潘子民，叶大风，谢幸，陈怀增，吕卫国
24．卵巢上皮性癌血管内皮生长因子mRNA异构体表达浙江大学学报（医学版）31<1>,傅云峰，谢幸，叶大风，陈怀增，吕卫国
25．甲氨蝶呤单药治疗低危妊娠滋养细胞肿瘤的疗效中国医学科学院学报25<4>,吕卫国，丁志明，谢幸，叶大风，陈怀增，冯素文
26．错配修复基因启动子甲基化和蛋白表达在葡萄胎的发生及恶变中的作用中国医学科学院学报25<4>,朱长琨，叶大风，谢幸，程晓东，陈怀增，吕卫国
27．卵巢癌细胞诱导T淋巴细胞凋亡的实验研究中华妇产科杂志38<9>,汪辉，李晓，谢幸，吕卫国，叶大风，陈怀增，程琪
28．几种细胞因子对人脐血CD34+干细胞在体外诱导扩增为树突状细胞的研究中华微生物学与免疫学杂志24<2>,叶枫，谢幸，叶大风，陈怀增，吕卫国
29．上皮性卵巢癌患者腹水白介素-10水平与其腹腔免疫功能缺陷关系的探讨癌症23<5>,周建维，程琪，谢幸，陈怀增，叶大风，吕卫国
30．phosphorylation of signal transducer and activators of transcription 3 induced by vascular endothelial growth factor in ovarian carcinoma cell line in vitro生长因子体外刺激卵巢癌细胞株信号转导及转录激活因子3中华妇产科杂志39<6>,王芬芬，陈怀增，谢幸，叶枫，叶大风，吕卫国，丁志明
31．Effect Of Vascular Endothelial Growth Factor (VEGF) On Differentiation And Function Of Dendritic Cells Generated From CD34+ Hematopoietic Progenitor Cells In VitroVEGF对CD34+干/祖细胞来源的树突状细胞分化及功能的影响中华血液学杂志25<9>,叶枫，陈怀增，谢幸，吕卫国
32．白细胞介素-2受体基因转染人外周血淋巴细胞的初步研究中国学术期刊文摘5<2>,谢幸，叶大风，陈怀增，吕卫国，程蓓
33．白介素-2及其受体基因对人外周血淋巴细胞杀卵巢癌细胞作用的影响中国学术期刊文摘5<6>,叶大风，谢幸，陈怀增，吕卫国，程蓓
34．IL-2基因转染对人卵巢癌细胞增殖、凋亡和MHC-Ⅱ的影响浙江医学23<2>,叶大风; 谢幸; 陈怀增; 吕卫国; 程蓓
35．超排卵时卵泡发育数与颗粒细胞胰岛素样生长因子Ⅰ受体的表达中华妇产科杂志36<2>,陈丹青，石一复，陈怀增
36．免疫重建荷人卵巢癌严重联合免疫缺陷鼠腹腔移植模型的建立中华医学杂志82<9>,朱华，叶大风，陈怀增，吕卫国，谢幸
37．人免疫重建荷人HPV16阳性宫颈癌-SCID鼠模型的建立及其生物学特性研究现代妇产科进展13<2>,梁朝霞，程琪，陈怀增，谢幸，叶大风
38．Altered expression of cellular membrane molecules of HLA-DR,HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma．Altered expression of cellular membrane molecules of HLA-DR,HLA-G and CD99 in cervical intraepithel78<22>,Zhou JH,Ye F,Chen HZ,Zhou CY,Lu WG,Xie X
39．Proportion of CD4+CD25+ regulatory T cell is increased in the patients with ovarian carcinomaProportion of CD4+CD25+ regulatory T cell is increased in the patients with ovarian carcinoma23<5>,Li X,Ye DF,Xie X,Chen HZ,Lu WG
40．Ovarian carcinoma cells effectively inhibit differentiation and maturation of dendritic cells derived from hematopoietic progenitor cells in vitroOvarian carcinoma cells effectively inhibit differentiation and maturation of dendritic cells deriveCancer Invest23<5>,Feng Ye,Huai-Zeng Chen,Xing Xie,Da-Feng Ye,Wei-Guo Lu,Zhi-Ming Ding
41．Tumor-infiltrating dendritic cells in epithelial ovarian carcinoma and correlation with the expression of vascular endothelial growth factor卵巢上皮性癌组织中肿瘤浸润性树突状细胞的状态及其与血管内皮生长因子表达的相关性中华妇产科杂志39<10>,毛俞燕，陈怀增，谢幸，叶大风，吕卫国
42．IL-2基因转染的人卵巢癌细胞对人外周血淋巴细胞杀瘤功能的影响实用妇产科杂志16<6>,叶大风，吕卫国，陈怀增，谢幸
43．人免疫重建荷人人乳头瘤病毒16阳性宫颈癌-严重联合免疫缺陷鼠模型的建立及其免疫学特性研究中华医学杂志84<17>,梁朝霞，程琪，陈怀增，谢幸，叶大风
44．Effect of interleukin-7 gene transfection into ovarian carcinoma cell line SKOV3 in vitro and in vivoEffect of interleukin-7 gene transfection into ovarian carcinoma cell line SKOV3 in vitro and in vivGynecologic Oncology92<>,Xing Xie,Da-Feng Ye,Huai-Zeng Chen,Wei-Guo Lu,Yun-Feng Fu,Bei Cheng,Hua Zhu
45．Growth inhibition of interleukin-2 receptor gene-transduced peripheral blood lymphocytes on human ovChin Med J (Engl)114<3>,Dafeng Ye,Xing Xie,Weiguo Lu,Huaizeng Chen,Bei Cheng
46．人类生长抑素受体mRNA在原发性肝癌中的表达中华消化杂志22<11>,刘建生，彭淑牖，吴育莲，陈怀增，彭承宏，Gao YY
47．人白细胞介素-7基因克隆及其真核表达载体的构建浙江大学学报（医学版）31<3>,程蓓，叶大风，谢幸，陈怀增，吕卫国
48．卵巢癌细胞对T细胞信号转导途径JAK-STAT的影响中华医学杂志83<11>,汪辉，谢幸，吕卫国，叶大风，陈怀增，李晓，程琪
49．血管内皮生长因子体外诱导CD34+造血干/祖细胞信号传导与转录活化因子的活化中国医学科学院学报26<1>,叶枫，叶大风，谢 幸，陈怀增，吕卫国
50．Vascular endothelial growth factor (VEGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (STATs) via VEGF receptor-2 (KDR) in human hemopoietic progVascular endothelial growth factor (VEGF) and ovarian carcinoma cell supernatant activate signal traGynecologic Oncology94<>,Feng Ye,Huai-Zeng Chen,Xing Xie,Da-Feng Ye,Wei-Guo Lu,Zhi-Ming Ding
51．Tapasin和HLAⅠ类分子在人卵巢癌中的表达及相关性中国肿瘤14<4>,52．HPV16E7肽疫苗对人免疫重建荷人宫颈癌细胞株SiHa细胞SCID鼠免疫功能的影响现代妇产科进展14<5>,53．人乳头瘤病毒的分子生物学特性研究现状国外医学．微生物学分册28<4>,54．卵巢上皮癌细胞中VEGF和VEGFRs的表达与STATs的活化中华肿瘤杂志27<1>,55．卵巢癌组织中肿瘤浸润淋巴细胞分布特征的研究中国实用妇科与产科杂志21<7>,56．宫颈癌遗传易感性的研究进展国外医学，遗传学分册28<6>,57．子宫颈鳞癌Ⅰb～Ⅱa期患者预后预测系统的建立及其临床意义中华妇产科杂志40<4>,58．早期宫颈鳞癌患者微淋巴管的分布及其临床意义中华医学杂志85<22>,59．在全子宫切除术后标本中发现的浸润性宫颈癌30例临床分析现代妇产科进展14<3>,60．细胞分裂方式及其发生机制研究进展医学分子生物学杂志2<6>,61．Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinomaLoss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous cEuropean Journal of Gynacological Oncology28<6>,Chen H,Ye F,Zhang J,Lu W,Cheng Q,Xie X
62．Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinomaLoss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous cEuropean Journal of Gynacological Oncology28<6>,Chen H,Ye F,Zhang J,Lu W,Cheng Q,Xie X
63．Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinomaLoss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous cEuropean Journal of Gynacological Oncology28<6>,Chen H,Ye F,Zhang J,Lu W,Cheng Q,Xie X
64．Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinomaLoss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous cEuropean Journal of Gynacological Oncology28<6>,Chen H,Ye F,Zhang J,Lu W,Cheng Q,Xie X
65．Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinomaLoss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous cEuropean Journal of Gynacological Oncology28<6>,Chen H,Ye F,Zhang J,Lu W,Cheng Q,Xie X
66．No association of the POLI Thr706Ala polymorphism with the risk of cervical carcinomaNo association of the POLI Thr706Ala polymorphism with the risk of cervical carcinomaEuropean Journal of Gynacological Oncology<>,Zhang J,Ye F,Cheng Q,Shen J,Chen H
67．Establishment of a cervical cancer model via inoculating SiHa Cells into humanized severe combined immunodeficient mice《EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY》27<6>,2006-08-25
68．Fas-mediated pathway and apoptosis in normal cervix,cervical intraepithelial neoplasia and cervical squamous cancer《onCOLOGY REPORTS》16<2>,2006-08-25
69．VEGF induces phosphorylation of STAT3 through binding VEGFR2 in ovarian carcinoma cells in vitro． Eur J Gynaecol Oncol《EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY》27<6>,2006-06-26
70．基因组CpG岛甲基化检测技术研究进展《国际遗传学杂志（原：国外医学：遗传学分册）》29<3>,2006-06-15
71．11q22-q25区候选抑癌基因OPCML、POU2F3、CUL-5启动子CpG岛甲基化与子宫颈癌的发生《实用肿瘤杂志》21<5>,2006-05-25
72．汉族妇女中p21codon31单核苷酸多态性与宫颈癌易感性关系的研究《现代妇产科进展》15<4>,2006-04-25
73．卵巢上皮性癌OPCML基因的表达缺失和启动子甲基化《中国医学科学院学报》28<2>,2006-04-25
74．汉族妇女中p21codon31单核苷酸多态性与宫颈癌易感性关系的研究《现代妇产科进展》15<4>,2006-04-25
75．卵巢上皮性癌细胞培养上清液增强CD4^CD25^＋调节性T淋巴细胞增殖及免疫抑制功能的实验研究《中华妇产科杂志》41<3>,2006-03-24
76．卵巢癌细胞培养上清诱导CD4^＋CD25^- T细胞分化为CD4^＋CD25^＋调节性T细胞《中华微生物学和免疫学杂志》26<2>,2006-02-24
77．局部晚期子宫颈癌新辅助化疗价值的评估《中华妇产科杂志》41<2>,2006-02-24
78．阴道镜直视下活检诊断宫颈上皮内瘤变准确性的评价《中华医学杂志》86<5>,2006-02-07
79．人乳头瘤病毒基因型检测方法的研究进展《国际检验医学杂志（原：国外医学：临床生物化学与检验学分册）》27<1>,2006-01-25
80．宫颈癌及上皮内瘤变人乳头瘤病毒基因型的检测《现代妇产科进展》15<1>,2006-01-25
81．Altered expression of cellular membrane molecules of HLA-DR,HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma《LIFE SCIENCES》78<22>,2006-01-24
82．expression in Normal Early Placentas and Hydatidiform Molesexpression in Normal Early Placentas and Hydatidiform MolesJ Soc Gynecol Investig12<>,20051201 Huaizeng Chen,Dafeng Ye,Xing Xie,Weiguo Lu,Changkun Zhu,Xiaodong Chen

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