南通大学药学院导师介绍：张伟

张伟： 男，1957年10月生，药理学教授，药理药剂内科学研究生导师。1990年6月研究生毕业于安徽医科大学心血管药理专业，获医学硕士学位，无党派人士。现任南通大学医学院药理学系主任；南通大学医药研究所所长；南通大学药学（省重点一级学科培育点）学科带头人；南通大学省优势学科《基础医学》学科（群） 学术带头人（PI）。社会兼职：南通伟康医药研究院院长（独立法人）；南通市生物医药重点实验室常务副主任。学术团体任职：中国药理学会理事；江苏省药理 学会副理事长；江苏省药理教学委员会副主任委员；江苏省新药临床前研究专业委员会副秘书长；南通市药学会药剂药理专业委员会主任委员。从事新药研究与开发 三十多年，先后主持或与企业合作承担各类中西医药研发项目30多项，绝大多数成果转化为生产力，其中有知名品牌盖天力、富硒康、安奇等，有 九五科技攻关项目抗高血压新药Moxonidine、抗炎新药Tenoxicam等，技术贸易（技术开发、技术服务、技术转让）达1000多万，近年 来主持国家、省、市厅级研究课题9项，获市厅级科技进步二等奖3项（名第一）,作为通讯作者（或第一作者）在国内外核心与权威期刊发表专业学术论文40多篇，拥有国家授权发明专利5项。
通讯作者（或第一作者）代表作：
15．Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells Int J Biochem Cell Biol．． 2013 Mar;45(3):736-44．
14．Two novel hydroperoxylated products of 20(S)-protopanaxadiol by Mucor racemosus and their cytotoxic activities against human prostate cancer cells Biotechnol Lett． 2013 Mar;35(3):439-43．
13．Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats． Biomed Pharmacother． 2012 Nov 15．doi:pii: S0753-3322PMID: 23178522
12．Microbial transformation of 20(S)-protopanaxadiol by Absidia corymbifera． Cytotoxic activity of the metabolites against human prostate cancer cells．
Fitoterapia． 2013 Jan;84:6-10
11．The effect of 2,3,4,5-tetrahydroxystilbene-2-0-ß-D glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms
Eur J Pharmacol． 2013 Jan ;698(1-3):370-8
10．MiR-17-3p Inhibits Angiogenesis by Downregulating Flk-1 in the Cell Growth Signal Pathway． J Vasc Res． 2012 Dec;50(2):157-166．
9．Electrical Field Stimulation Induces Cardiac Fibroblast Proliferation through Calcineurin-NFAT Pathway．
Can J Physiol Pharmacol． 2012 Dec;90(12):1611-22．
8．SKF83959,an Agonist of the Phosphatidylinositol-linked D1-Like Receptors,Promotes ERK1/2Activation and Cell Migration in Cultured Rat Astrocytes．
PLoS One． 2012 Nov;7(11):e49954．
7．2,3,4’,5-Tetrahydroxystilbene-2-0-beta-D-glucoside inhibits proliferation of
Vascular smooth muscle cells：involvement of NO/cGMP/PKG pathway．
Phytotherapy Research． 2012 Jul;26(7):1068-74
6．2,3,4,5-Tetrahydroxystilbene-2-O-beta-D-glucoside Inhibits angiotensin II-induced
cardiac fibroblast proliferation through suppression of reactive oxygen species-ERK1/2
pathway． Clin Exp Pharmacol Physiol． 2012 May;39(5):429-37．
5．2,3,4,5-Tetrahydroxystilbene-2-0-beta-D-glucoside inhibits platelet-derived growth
factor-induced proliferation of vascular smooth muscle cells by regulating cell cycle．
Clin Exp Pharmacol Physiol． 2011May;38(5):307–313
4．Ca2+⁄calmodulin-dependent protein kinase IIδ orchestrates G-protein-coupled
receptor and electric field stimulation-induced cardiomyocyte hypertrophy
Clin Exp Pharmacol Physiol 2010 Aug;37(8):795–802
3．Inhibition of Calcium-Calmodulin-Dependent Kinase II Suppress Cardiac
Fibroblast Proliferation and Extracellular Matrix Secretion ．
J Cardiovasc Pharmacol 2010 Jan;55(1):96-105
2．Effects of 2,3,4’,5-Tetrahydroxystilbene-2-0-β-D-glucoside on vascular endothelial
dysfunction in atherogenic-diet rats Planta Medicinal 2009 Sep;75:1209-1214
1．2,3,4’,5-TETRAHYDROXYSTILBENE-2-O-β-D-GLUCOSIDE SUPPRESSES MATRIX metaLLOPROTEINASE expression AND INFLAMMATION IN ATHEROSCLEROTIC
RATS． Clin Exp Pharmacol Physiol 2008 Mar;35(3):310-6．
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