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发布时间: 2024年11月24日 15:50
戴岳,男,博士,教授,博士生导师。1985年毕业于中国药科大学药理学专业,1988年在同校中药药理专业获硕士学位后留校任教,1998年在日本近畿大学药学部获得药学博士学位,曾在近畿大学药学部和香港中文大学中药研究所合作研究三年。担任中国药科大学中药学院副院长、中药药理教研室主任,江苏省333高层次人才培养工程首批中青年科学技术带头人,江苏省教育厅青蓝工程中青年学术带头人,国家留学基金评审专家,教育部留学回国人员科研启动基金评审专家,国家和江苏省新药评审专家,国家自然科学基金、863计划项目同行评议专家。Journal of Pharmacy and Pharmacology、International Immunopharmacology、Journal of Ethnopharmacology、Acta Pharmacologica Sinca等6种国际刊物通讯评议人。
主要从事中药抗炎免疫药理学研究,主持过国家自然科学基金、科技重大专项重大新药创制、国家新药基金等国家级和省部级科研项目14项,参加12项,转让降血糖五类中药新药1个。作为副主编/编委参编《新编临床中药学》、《中药药理研究方法学》和《中国药材学》等专著5部。主讲过中药药理学、 免疫学和免疫药理学等五门本科和研究生课程,获江苏省教育厅教学成果奖1项。已发表研究论文135篇(SCI收录49篇),获授权发明专利8项。目前主持国家自然科学基金面上项目2项、高等学校博士学科点专项科研基金项目1项,指导博、硕士研究生22名。
研究工作集中在以下几个方面:1)中药活性成分干预滑膜血管生成的分子靶点研究;2)难吸收中药活性成分作用机制的研究;3)抗类风湿关节炎中药新药的研制。
近期代表性论文(通讯作者)
1. Treatment with total alkaloids from Radix Linderae reduces inflammation and joint destruction in type II collagen-induced arthritis model of rheumatoid arthritis. Journal of Ethnopharmacology 2007,4;111:322-8
2. Madecassoside Isolated from Centella asiatica Herbs Facilitates Burn Wound Healing in Mice. Planta Medica,2008; 74: 809-15
3. Madecassoside inhibits type II collagen-induced arthritis in mice. International Immunopharmacology 2008; 8:1561-6
4. Total alkaloids from Radix Linderae prevent the production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells by suppressing NF-κB and MAPKs activation. Cytokine 2009;46:104-10
5. Scopolin isolated from Erycibe obtusifolia Benth stems suppresses adjuvant-induced rat arthritis by inhibiting inflammation and angiogenesis. International Immunopharmacology 2009;9:859-69.
6. Anti-arthritic Effect of Scopoletin,a coumarin compound occurring in Erycibe obtusifolia Benth Stems,is associated with decreased angiogenesis in synovium. Fundamental Clinical Pharmacology 2010,24(4):477-90
7. Heparin: an intervenor in cell communication. Journal of Cellular and Molecular Medicine 2010,14(1-2):175-180
8. (±)-Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis Chem-Biol Interaction 2010,186:239-246
9. Therapeutic effect of norisoboldine,an alkaloid isolated from Radix Linderae,on collagen-induced arthritis in mice Phytomedicine 2010,17: 726-731
10. Inhibition of vascular endothelial growth factor (VEGF)-induced angiogenesis by scopoletin through interrupting the autophosphorylation of VEGF receptor 2 (VEGFR2) and its downstream signaling pathways. Vascular Pharmacology 2011,54:18-28
11. Paeoniflorin protects against lipopolysaccharide-induced acute lung injury in mice by alleviating inflammatory cell infiltration and microvascular permeability. Inflammation Research 2011,60(10):981–990
12. Prevention of bFGF-induced angiogenesis by scopoletin,a coumarin compound isolated from Erycibe obtusifolia Benth,and its mechanism of action. International Immunopharmacology 2011 Sep 5. [Epub ahead of print]
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